Alcohol and aldehyde dehydrogenase isoenzymes in Sioux North Americal Indians
Because alcohol-dependent facial flushing has been observed in some North American Indians and they are considered to be members of the Mongoloid major mating population, the distribution of ADH and ALDH isoenzymes in American Indian populations has been a subject of much interest. To further characterize the ADH and ALDH isoenzyme variation in North American Indians, we have examined their distribution in 33 liver autopsy specimens from Lakota Sioux Indians from South Dakota. The conclusion from this study of Sioux Indians is similar to that of our previous study in Navajo Indians; that is, any difference in frequency of alcoholism between these North American Indian populations and White Americans or any similarity to Japanese in sensitivity to alcohol consumption, such as the flushing reaction, cannot be attributed to differences in the type of ADH or ALDH isoenzymes present in these groups.
Bosron, WF; Rex, DK; Harden, CA; Li, TK; Akerson, RD
Alcoholism: Clinical and Experimental Research
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