Study on drug release of hydrogel films made of cross-linked hyaluronic acid derivatives in vitro
OBJECTIVE: To evaluate drug release properties in vitro of the hydrogel films made of cross-linked hyaluronic acid derivatives. METHODS: The drug releases rates of the hydrogel films were measured by using dictyo-dish method. The effects of contents of cross-linking reagent in the hydrogel films and the release medium with hyalouronidase (HAse) were investigated. RESULTS: The releases of some hydrophobic drugs from the hydrogel films were significantly sustained and the drug release patterns followed Higuchi equation. Drug release rates were delayed by increasing contents of cross-linking reagent, while were quickened by using the medium with HAse. CONCLUSION: The hydrogel films made of cross-linked hyaluronic acid derivatives have excellent potentials as carriers for the sustained release of some hydrophobic drugs.