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Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.

Publication ,  Journal Article
Rambod, M; Porszasz, J; Make, BJ; Crapo, JD; Casaburi, R; COPDGene Investigators,
Published in: Chest
April 2012

BACKGROUND: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV(1). We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort. METHODS: COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. Phenotyping measures include postbronchodilator FEV(1) % predicted and inspiratory and expiratory CT lung scans. We defined % emphysema as the percentage of lung voxels < -950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels < -856 Hounsfield units on the expiratory scan. RESULTS: Data of the first 2,500 participants of the COPDGene cohort were analyzed. Participant age was 61 ± 9 years; 51% were men; 76% were non-Hispanic Caucasians, and 24% were African Americans. Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Higher % emphysema and % gas trapping predicted lower 6MWD (P < .001). However, in a given spirometric group, after adjustment for age, sex, race, and BMI, neither % emphysema nor % gas trapping, or their interactions with FEV(1) % predicted, remained a significant 6MWD predictor. In a given spirometric group, only 16% to 27% of the variance in 6MWD could be explained by age, male sex, Caucasian race, and lower BMI as significant predictors of higher 6MWD. CONCLUSIONS: In this large cohort of smokers in a given spirometric stage, phenotypic characteristics were only modestly predictive of 6MWD. CT scan measures of emphysema and gas trapping were not predictive of 6MWD after adjustment for other phenotypic characteristics.

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

April 2012

Volume

141

Issue

4

Start / End Page

867 / 875

Location

United States

Related Subject Headings

  • Walking
  • Tomography, X-Ray Computed
  • Time Factors
  • Spirometry
  • Smoking
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Middle Aged
  • Male
  • Humans
 

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Rambod, M., Porszasz, J., Make, B. J., Crapo, J. D., Casaburi, R., & COPDGene Investigators, . (2012). Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest, 141(4), 867–875. https://doi.org/10.1378/chest.11-0870
Rambod, Mehdi, Janos Porszasz, Barry J. Make, James D. Crapo, Richard Casaburi, and Richard COPDGene Investigators. “Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.Chest 141, no. 4 (April 2012): 867–75. https://doi.org/10.1378/chest.11-0870.
Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R, COPDGene Investigators. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr;141(4):867–75.
Rambod, Mehdi, et al. “Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.Chest, vol. 141, no. 4, Apr. 2012, pp. 867–75. Pubmed, doi:10.1378/chest.11-0870.
Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R, COPDGene Investigators. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr;141(4):867–875.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

April 2012

Volume

141

Issue

4

Start / End Page

867 / 875

Location

United States

Related Subject Headings

  • Walking
  • Tomography, X-Ray Computed
  • Time Factors
  • Spirometry
  • Smoking
  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Middle Aged
  • Male
  • Humans