NF1-related locus on chromosome 15.

Published

Journal Article

A neurofibromatosis type I (NF1)-related locus has been identified on chromosome 15. It contains a partial copy of the NF1 GAP-related domain, which is known to interact with the ras protooncogenes. However, the chromosome 15 sequence contains multiple deletions resulting in frameshift mutations and stop codons in several highly conserved sequence blocks. The locus on chromosome 15 therefore represents an NF1 pseudogene. This nonprocessed NF1 pseudogene may produce additional fragments in Southern blotting, pulsed-field gel, and PCR experiments with some NF1 cDNA probes or oligonucleotides. In addition, certain regions of the NF1 gene also cross-hybridize with a locus on chromosome 14. These loci must be considered in mutation analysis of patients with NF1 since aberrant findings may not always reflect changes in the NF1 gene.

Full Text

Duke Authors

Cited Authors

  • Legius, E; Marchuk, DA; Hall, BK; Andersen, LB; Wallace, MR; Collins, FS; Glover, TW

Published Date

  • August 1992

Published In

Volume / Issue

  • 13 / 4

Start / End Page

  • 1316 - 1318

PubMed ID

  • 1505963

Pubmed Central ID

  • 1505963

International Standard Serial Number (ISSN)

  • 0888-7543

Language

  • eng

Conference Location

  • United States