The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

Journal Article (Journal Article)

The von Recklinghausen neurofibromatosis locus, NF1, encodes a protein with homology restricted to the catalytic region of the RAS GTPase-activating protein, GAP, and with extensive homology to the IRA1 and IRA2 gene products of the yeast S. cerevisiae. A segment of the NF1 cDNA gene, expressed in yeast, can complement loss of IRA function and can inhibit both wild-type and mutant activated human H-ras genes that are coexpressed in yeast. Yeast expressing the NF1 segment have increased H-ras GTPase-stimulating activity. These studies indicate that the NF1 gene product can interact with RAS proteins and demonstrate structural and functional similarities and differences among the GAP, IRA1, IRA2, and NF1 proteins.

Full Text

Duke Authors

Cited Authors

  • Ballester, R; Marchuk, D; Boguski, M; Saulino, A; Letcher, R; Wigler, M; Collins, F

Published Date

  • November 16, 1990

Published In

Volume / Issue

  • 63 / 4

Start / End Page

  • 851 - 859

PubMed ID

  • 2121371

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(90)90151-4


  • eng

Conference Location

  • United States