Expression of unusually large keratins during terminal differentiation: balance of type I and type II keratins is not disrupted.

Published

Journal Article

When a basal epidermal cell undergoes a commitment to terminally differentiate, it ceases to divide and begins to migrate outward towards the surface of the skin. Dramatic changes in its cytoskeletal architecture take place, accompanied by numerous changes in the expression of keratins, a family of related polypeptides that form 8-nm filaments in these cells. We show here that a shift to the synthesis of unusually large keratins occurs that does not seem to disrupt the ratio of two distinct subfamilies of keratins. Preliminary studies indicate that this differentiation-specific shift may be at the level of transcriptional rather than post-transcriptional regulation. The striking similarities between these large keratins and the type I and type II keratins of basal epidermal cells suggests the important role that both classes of large keratin sequences must play in the assembly of the intermediate filaments within the differentiating keratinocyte.

Full Text

Duke Authors

Cited Authors

  • Kim, KH; Marchuk, D; Fuchs, E

Published Date

  • November 1984

Published In

Volume / Issue

  • 99 / 5

Start / End Page

  • 1872 - 1877

PubMed ID

  • 6208205

Pubmed Central ID

  • 6208205

Electronic International Standard Serial Number (EISSN)

  • 1540-8140

International Standard Serial Number (ISSN)

  • 0021-9525

Digital Object Identifier (DOI)

  • 10.1083/jcb.99.5.1872

Language

  • eng