Skip to main content

Efficacy of risperidone on positive features of schizophrenia.

Publication ,  Journal Article
McEvoy, JP
Published in: J Clin Psychiatry
May 1994

Dopaminergic hyperactivity mediated via D2 receptors is implicated in the etiology of positive symptoms of schizophrenia, but selective D2 antagonists provide imperfect therapy. This article describes a subanalysis of a trial of risperidone, a combined 5-HT2A/D2 antagonist, in 513 patients with DSM-III-R chronic schizophrenia. Risperidone at 2, 6, 10, and 16 mg/day was compared with placebo and haloperidol 20 mg/day. All doses of risperidone and the 20-mg dose of haloperidol were superior to placebo (mean change from baseline on the PANSS positive and general psychopathology subscales). The 6-mg dose of risperidone also produced significantly more improvement than haloperidol 20 mg. We conclude that risperidone is an effective drug for patients with positive features of schizophrenia.

Duke Scholars

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

May 1994

Volume

55 Suppl

Start / End Page

18 / 21

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Schizophrenia
  • Risperidone
  • Receptors, Serotonin
  • Receptors, Dopamine D2
  • Psychiatry
  • Piperidines
  • Isoxazoles
  • Humans
  • Haloperidol
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McEvoy, J. P. (1994). Efficacy of risperidone on positive features of schizophrenia. J Clin Psychiatry, 55 Suppl, 18–21.
McEvoy, J. P. “Efficacy of risperidone on positive features of schizophrenia.J Clin Psychiatry 55 Suppl (May 1994): 18–21.
McEvoy JP. Efficacy of risperidone on positive features of schizophrenia. J Clin Psychiatry. 1994 May;55 Suppl:18–21.
McEvoy, J. P. “Efficacy of risperidone on positive features of schizophrenia.J Clin Psychiatry, vol. 55 Suppl, May 1994, pp. 18–21.
McEvoy JP. Efficacy of risperidone on positive features of schizophrenia. J Clin Psychiatry. 1994 May;55 Suppl:18–21.

Published In

J Clin Psychiatry

ISSN

0160-6689

Publication Date

May 1994

Volume

55 Suppl

Start / End Page

18 / 21

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Schizophrenia
  • Risperidone
  • Receptors, Serotonin
  • Receptors, Dopamine D2
  • Psychiatry
  • Piperidines
  • Isoxazoles
  • Humans
  • Haloperidol