A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressives

Journal Article

In a multicenter series of trials, viloxazine was compared with imipramine, amitriptyline, doxepin and placebo in 123 neurotic and endogenous depressive inpatients and outpatients. While significant period effects reflecting improvement were obtained on the majority of efficacy variables, no significant differences were obtained among the treatment groups or depressive types. Imipramine and amitriptyline exhibited more anticholinergic adverse reactions; while, viloxazine exhibited greater CNS effects. Dizziness and nausea were much more frequent in neurotic depressives which may be related to their psychopathology.

Duke Authors

Cited Authors

  • Guy, W; Ban, TA; McEvoy, JP; Petrie, WM; Wilson, WH; Schaffer, JD

Published Date

  • 1982

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 36 - 42

International Standard Serial Number (ISSN)

  • 0020-8272