A double-blind comparison of three dosages of flutroline (CP-36,584) in the treatment of schizophrenia

Journal Article

Therapeutic and adverse effects of three dosages (1, 20 and 100 mg daily) of flutroline, a new γ-carboline with a preclinical pharmacological profile similar to active neuroleptic agents, were compared in a double-blind clinical trial in 25 newly-admitted schizophrenic patients. Therapeutic effects and extrapyramidal signs were seen at the 20 and 100-mg daily dosages, but not at the 1-mg dosage. Serum prolactin levels were significantly elevated only at the 100-mg daily dose.

Duke Authors

Cited Authors

  • McEvoy, JP; Berney, S; Wilson, WH; Ban, TA; Guy, W

Published Date

  • 1980

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 318 - 324

International Standard Serial Number (ISSN)

  • 0020-8272