Chromosomal localization of human glutamate receptor genes.

Published

Journal Article

The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR 1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22-23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral-renal syndrome of Lowe and a form of manic-depressive illness.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO; Eubanks, JH; McPherson, JD; Wasmuth, JJ; Evans, GA; Heinemann, SF

Published Date

  • July 1992

Published In

Volume / Issue

  • 12 / 7

Start / End Page

  • 2555 - 2562

PubMed ID

  • 1319477

Pubmed Central ID

  • 1319477

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.12-07-02555.1992

Language

  • eng