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Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.

Publication ,  Journal Article
Shin, C; McNamara, JO; Morgan, JI; Curran, T; Cohen, DR
Published in: J Neurochem
September 1990

Periodic induction of focal electrical seizure [afterdischarge (AD)] is an absolute prerequisite for the development of kindling, an animal model of complex partial epilepsy. Once established, it is a permanent condition. The mechanism(s) that translate ADs, which last tens of seconds, into life-long alterations in the CNS is unclear. Cellular immediate-early genes have been implicated in the conversion of short-term stimuli to long-term alterations in cellular phenotypes by regulating target gene expression. We have investigated the contribution of one such early gene, c-fos, to this process. The relationship between ADs and expression of c-fos gene in the rat hippocampus, a key structure in kindling development, was studied by analysis of mRNA levels. The low constitutive expression of c-fos mRNA in the hippocampus was not altered by kindling. There was an "all-or-none" relationship between induction of c-fos and the duration of AD. The threshold for induction was approximately 30 s of AD. Above-threshold ADs induced c-fos in both naive and kindled animals to the same extent and with identical temporal profiles. Although the expression of c-fos is unchanged with kindling, c-fos may nonetheless contribute to many long-term changes of kindling, both adaptive and epileptogenic.

Duke Scholars

Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

September 1990

Volume

55

Issue

3

Start / End Page

1050 / 1055

Location

England

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins
  • Neurology & Neurosurgery
  • Kinetics
  • Kindling, Neurologic
  • Hippocampus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shin, C., McNamara, J. O., Morgan, J. I., Curran, T., & Cohen, D. R. (1990). Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem, 55(3), 1050–1055. https://doi.org/10.1111/j.1471-4159.1990.tb04595.x
Shin, C., J. O. McNamara, J. I. Morgan, T. Curran, and D. R. Cohen. “Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.J Neurochem 55, no. 3 (September 1990): 1050–55. https://doi.org/10.1111/j.1471-4159.1990.tb04595.x.
Shin C, McNamara JO, Morgan JI, Curran T, Cohen DR. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem. 1990 Sep;55(3):1050–5.
Shin, C., et al. “Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats.J Neurochem, vol. 55, no. 3, Sept. 1990, pp. 1050–55. Pubmed, doi:10.1111/j.1471-4159.1990.tb04595.x.
Shin C, McNamara JO, Morgan JI, Curran T, Cohen DR. Induction of c-fos mRNA expression by afterdischarge in the hippocampus of naive and kindled rats. J Neurochem. 1990 Sep;55(3):1050–1055.
Journal cover image

Published In

J Neurochem

DOI

ISSN

0022-3042

Publication Date

September 1990

Volume

55

Issue

3

Start / End Page

1050 / 1055

Location

England

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • RNA, Messenger
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins
  • Neurology & Neurosurgery
  • Kinetics
  • Kindling, Neurologic
  • Hippocampus