Electrolytic entorhinal lesions cause seizures.


Journal Article

The entorhinal cortex is a key site of interneuronal communication between a variety of cortical and subcortical areas and hippocampal formation. Lesioning the entorhinal cortex is commonly used in studies of the hippocampal formation, animal behavior and neuronal plasticity. We have found that electrolytic destruction of the entorhinal cortex consistently produces limbic seizure activity in rats. The propensity of lesions in this area for producing seizure activity may facilitate insights into the normal function of this network of neural connections. This unexpected phenomenon represents a potential confounding variable for all researchers using this method for making brain lesions.

Full Text

Duke Authors

Cited Authors

  • Dasheiff, RM; McNamara, JO

Published Date

  • January 14, 1982

Published In

Volume / Issue

  • 231 / 2

Start / End Page

  • 444 - 450

PubMed ID

  • 7055687

Pubmed Central ID

  • 7055687

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(82)90381-x


  • eng

Conference Location

  • Netherlands