Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.

Journal Article (Journal Article)

Amygdala-kindled seizures reduced significantly the total number of [3H]quinuclidinyl benzilate binding sites in both dentate and hippocampal gyri compared to electrode implanted unstimulated controls. Both high and low affinity carbachol displaceable binding site populations were significantly reduced in hippocampal gyrus. By contrast, a selective decline of low affinity sites was found in dentate gyrus membranes. The selectivity of the decline in dentate but not hippocampus gyrus underscores the specificity of this molecular response to amygdala-kindled seizures. We suggest that these receptor alterations underlie adaptive mechanisms which antagonize kindled epileptogenesis.

Full Text

Duke Authors

Cited Authors

  • Savage, DD; McNamara, JO

Published Date

  • September 1982

Published In

Volume / Issue

  • 222 / 3

Start / End Page

  • 670 - 673

PubMed ID

  • 7108770

International Standard Serial Number (ISSN)

  • 0022-3565


  • eng

Conference Location

  • United States