Kindled seizures selectively reduce a subpopulation of [3H]quinuclidinyl benzilate binding sites in rat dentate gyrus.
Journal Article
Amygdala-kindled seizures reduced significantly the total number of [3H]quinuclidinyl benzilate binding sites in both dentate and hippocampal gyri compared to electrode implanted unstimulated controls. Both high and low affinity carbachol displaceable binding site populations were significantly reduced in hippocampal gyrus. By contrast, a selective decline of low affinity sites was found in dentate gyrus membranes. The selectivity of the decline in dentate but not hippocampus gyrus underscores the specificity of this molecular response to amygdala-kindled seizures. We suggest that these receptor alterations underlie adaptive mechanisms which antagonize kindled epileptogenesis.
Full Text
Duke Authors
Cited Authors
- Savage, DD; McNamara, JO
Published Date
- September 1982
Published In
Volume / Issue
- 222 / 3
Start / End Page
- 670 - 673
PubMed ID
- 7108770
Pubmed Central ID
- 7108770
International Standard Serial Number (ISSN)
- 0022-3565
Language
- eng
Conference Location
- United States