Effects of oral choline on human complex partial seizures.


Journal Article

We carried out an open study of the effects of large doses (12 to 16 gm per day) of oral choline on medically intractable human complex partial seizures (CPS). Marked increases of plasma choline concentration (75 to 300%) in three subjects were associated with (1) shorter duration of CPS, (2) less postseizure fatigue, and (3) slight increase of seizure frequency. Both the patients and their families considered the patients much improved. No differences in any of these evaluations were noted in a fourth subject who had less of an increase (21%) of plasma choline content. The results suggest that oral choline therapy may be a useful adjunct in the treatment of intractable CPS. A blinded prospective study will be necessary to assess this possibility.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO; Carwile, S; Hope, V; Luther, J; Miller, P

Published Date

  • December 1, 1980

Published In

Volume / Issue

  • 30 / 12

Start / End Page

  • 1334 - 1336

PubMed ID

  • 6779220

Pubmed Central ID

  • 6779220

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.30.12.1334


  • eng

Conference Location

  • United States