Skip to main content
Journal cover image

Muscarinic cholinergic regulation of epileptic spiking in kindling.

Publication ,  Journal Article
Fitz, JG; McNamara, JO
Published in: Brain Res
December 7, 1979

Electroencephalographic monitoring of spontaneous interictal spiking (SIS) following kindling demonstrated that SIS occurs in both amygdalas and that it declines sharply during the days following kindling. Systemically administered muscarinic antagonists which pass the blood-brain barrier (atropine and scopolamine) activated interictal spiking in kindled rats but not in controls. Interictal spiking activated by atropine was reversed by physostigmine. Both physostigmine and choline, agents which increase brain ACh concentration by different mechanisms, caused a reduction in spontaneous (not drug activated) interictal spiking. The results of these pharmacologic studies indicate that the interaction of endogenous ACh with central muscarinic receptors is capable of suppressing SIS in kindled rats. Whether cholinergic suppression of SIS represents a convulsant or an anticonvulsant action is presently unclear.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 7, 1979

Volume

178

Issue

1

Start / End Page

117 / 127

Location

Netherlands

Related Subject Headings

  • Seizures
  • Scopolamine
  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Rats
  • Physostigmine
  • Neurology & Neurosurgery
  • Male
  • Electric Stimulation
  • Brain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fitz, J. G., & McNamara, J. O. (1979). Muscarinic cholinergic regulation of epileptic spiking in kindling. Brain Res, 178(1), 117–127. https://doi.org/10.1016/0006-8993(79)90092-1
Fitz, J. G., and J. O. McNamara. “Muscarinic cholinergic regulation of epileptic spiking in kindling.Brain Res 178, no. 1 (December 7, 1979): 117–27. https://doi.org/10.1016/0006-8993(79)90092-1.
Fitz JG, McNamara JO. Muscarinic cholinergic regulation of epileptic spiking in kindling. Brain Res. 1979 Dec 7;178(1):117–27.
Fitz, J. G., and J. O. McNamara. “Muscarinic cholinergic regulation of epileptic spiking in kindling.Brain Res, vol. 178, no. 1, Dec. 1979, pp. 117–27. Pubmed, doi:10.1016/0006-8993(79)90092-1.
Fitz JG, McNamara JO. Muscarinic cholinergic regulation of epileptic spiking in kindling. Brain Res. 1979 Dec 7;178(1):117–127.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 7, 1979

Volume

178

Issue

1

Start / End Page

117 / 127

Location

Netherlands

Related Subject Headings

  • Seizures
  • Scopolamine
  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Rats
  • Physostigmine
  • Neurology & Neurosurgery
  • Male
  • Electric Stimulation
  • Brain