Methyl-directed DNA mismatch repair in Escherichia coli.
Publication
, Journal Article
Lahue, RS; Modrich, P
Published in: Mutat Res
March 1988
Some of the molecular aspects of methyl-directed mismatch repair in E. coli have been characterized. These include: mismatch recognition by mutS protein in which different mispairs are bound with different affinities; the direct involvement of d(GATC) sites; and strand scission by mutH protein at d(GATC) sequences with strand selection based on methylation of the DNA at those sites. In addition, communication over a distance between a mismatch and d(GATC) sites has been implicated. Analysis of mismatch correction in a defined system (Lahue et al., unpublished) should provide a direct means to further molecular aspects of this process.
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Published In
Mutat Res
DOI
ISSN
0027-5107
Publication Date
March 1988
Volume
198
Issue
1
Start / End Page
37 / 43
Location
Netherlands
Related Subject Headings
- Site-Specific DNA-Methyltransferase (Adenine-Specific)
- Oncology & Carcinogenesis
- Methyltransferases
- Methylation
- Escherichia coli
- Endodeoxyribonucleases
- DNA-Binding Proteins
- DNA, Bacterial
- DNA Repair
- DNA Ligases
Citation
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Lahue, R. S., & Modrich, P. (1988). Methyl-directed DNA mismatch repair in Escherichia coli. Mutat Res, 198(1), 37–43. https://doi.org/10.1016/0027-5107(88)90037-1
Lahue, R. S., and P. Modrich. “Methyl-directed DNA mismatch repair in Escherichia coli.” Mutat Res 198, no. 1 (March 1988): 37–43. https://doi.org/10.1016/0027-5107(88)90037-1.
Lahue RS, Modrich P. Methyl-directed DNA mismatch repair in Escherichia coli. Mutat Res. 1988 Mar;198(1):37–43.
Lahue, R. S., and P. Modrich. “Methyl-directed DNA mismatch repair in Escherichia coli.” Mutat Res, vol. 198, no. 1, Mar. 1988, pp. 37–43. Pubmed, doi:10.1016/0027-5107(88)90037-1.
Lahue RS, Modrich P. Methyl-directed DNA mismatch repair in Escherichia coli. Mutat Res. 1988 Mar;198(1):37–43.
Published In
Mutat Res
DOI
ISSN
0027-5107
Publication Date
March 1988
Volume
198
Issue
1
Start / End Page
37 / 43
Location
Netherlands
Related Subject Headings
- Site-Specific DNA-Methyltransferase (Adenine-Specific)
- Oncology & Carcinogenesis
- Methyltransferases
- Methylation
- Escherichia coli
- Endodeoxyribonucleases
- DNA-Binding Proteins
- DNA, Bacterial
- DNA Repair
- DNA Ligases