Methyl-directed DNA mismatch repair in Escherichia coli.

Published

Journal Article

Some of the molecular aspects of methyl-directed mismatch repair in E. coli have been characterized. These include: mismatch recognition by mutS protein in which different mispairs are bound with different affinities; the direct involvement of d(GATC) sites; and strand scission by mutH protein at d(GATC) sequences with strand selection based on methylation of the DNA at those sites. In addition, communication over a distance between a mismatch and d(GATC) sites has been implicated. Analysis of mismatch correction in a defined system (Lahue et al., unpublished) should provide a direct means to further molecular aspects of this process.

Full Text

Duke Authors

Cited Authors

  • Lahue, RS; Modrich, P

Published Date

  • March 1988

Published In

Volume / Issue

  • 198 / 1

Start / End Page

  • 37 - 43

PubMed ID

  • 3280983

Pubmed Central ID

  • 3280983

International Standard Serial Number (ISSN)

  • 0027-5107

Digital Object Identifier (DOI)

  • 10.1016/0027-5107(88)90037-1

Language

  • eng

Conference Location

  • Netherlands