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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Publication ,  Journal Article
Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL ...
Published in: Science
April 6, 2001

Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 6, 2001

Volume

292

Issue

5514

Start / End Page

69 / 74

Location

United States

Related Subject Headings

  • Viral Load
  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines, DNA
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Macaca mulatta
 

Citation

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Amara, R. R., Villinger, F., Altman, J. D., Lydy, S. L., O’Neil, S. P., Staprans, S. I., … Robinson, H. L. (2001). Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science, 292(5514), 69–74. https://doi.org/10.1126/science.1058915
Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O’Neil, S. I. Staprans, D. C. Montefiori, et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.Science 292, no. 5514 (April 6, 2001): 69–74. https://doi.org/10.1126/science.1058915.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science. 2001 Apr 6;292(5514):69–74.
Amara, R. R., et al. “Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.Science, vol. 292, no. 5514, Apr. 2001, pp. 69–74. Pubmed, doi:10.1126/science.1058915.
Amara RR, Villinger F, Altman JD, Lydy SL, O’Neil SP, Staprans SI, Montefiori DC, Xu Y, Herndon JG, Wyatt LS, Candido MA, Kozyr NL, Earl PL, Smith JM, Ma HL, Grimm BD, Hulsey ML, Miller J, McClure HM, McNicholl JM, Moss B, Robinson HL. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science. 2001 Apr 6;292(5514):69–74.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 6, 2001

Volume

292

Issue

5514

Start / End Page

69 / 74

Location

United States

Related Subject Headings

  • Viral Load
  • Vaccinia virus
  • Vaccines, Synthetic
  • Vaccines, DNA
  • T-Lymphocytes
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Macaca mulatta