Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.

Published

Journal Article

Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.

Full Text

Duke Authors

Cited Authors

  • Amara, RR; Villinger, F; Altman, JD; Lydy, SL; O'Neil, SP; Staprans, SI; Montefiori, DC; Xu, Y; Herndon, JG; Wyatt, LS; Candido, MA; Kozyr, NL; Earl, PL; Smith, JM; Ma, HL; Grimm, BD; Hulsey, ML; Miller, J; McClure, HM; McNicholl, JM; Moss, B; Robinson, HL

Published Date

  • April 2001

Published In

Volume / Issue

  • 292 / 5514

Start / End Page

  • 69 - 74

PubMed ID

  • 11393868

Pubmed Central ID

  • 11393868

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1058915

Language

  • eng