An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants.

Journal Article (Journal Article)

We developed an AIDS vaccine based on attenuated VSV vectors expressing env and gag genes and tested it in rhesus monkeys. Boosting was accomplished using vectors with glycoproteins from different VSV serotypes. Animals were challenged with a pathogenic AIDS virus (SHIV89.6P). Control monkeys showed a severe loss of CD4+ T cells and high viral loads, and 7/8 progressed to AIDS with an average time of 148 days. All seven vaccinees were initially infected with SHIV89.6P but have remained healthy for up to 14 months after challenge with low or undetectable viral loads. Protection from AIDS was highly significant (p = 0.001). VSV vectors are promising candidates for human AIDS vaccine trials because they propagate to high titers and can be delivered without injection.

Full Text

Duke Authors

Cited Authors

  • Rose, NF; Marx, PA; Luckay, A; Nixon, DF; Moretto, WJ; Donahoe, SM; Montefiori, D; Roberts, A; Buonocore, L; Rose, JK

Published Date

  • September 7, 2001

Published In

Volume / Issue

  • 106 / 5

Start / End Page

  • 539 - 549

PubMed ID

  • 11551502

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(01)00482-2


  • eng

Conference Location

  • United States