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Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles.

Publication ,  Journal Article
Davis, NL; Caley, IJ; Brown, KW; Betts, MR; Irlbeck, DM; McGrath, KM; Connell, MJ; Montefiori, DC; Frelinger, JA; Swanstrom, R; Johnson, PR ...
Published in: J Virol
January 2000

Vaccine vectors derived from Venezuelan equine encephalitis virus (VEE) that expressed simian immunodeficiency virus (SIV) immunogens were tested in rhesus macaques as part of the effort to design a safe and effective vaccine for human immunodeficiency virus. Immunization with VEE replicon particles induced both humoral and cellular immune responses. Four of four vaccinated animals were protected against disease for at least 16 months following intravenous challenge with a pathogenic SIV swarm, while two of four controls required euthanasia at 10 and 11 weeks. Vaccination reduced the mean peak viral load 100-fold. The plasma viral load was reduced to below the limit of detection (1,500 genome copies/ml) in one vaccinated animal between 6 and 16 weeks postchallenge and in another from week 6 through the last sampling time (40 weeks postchallenge). The extent of reduction in challenge virus replication was directly correlated with the strength of the immune response induced by the vectors, which suggests that vaccination was effective.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

January 2000

Volume

74

Issue

1

Start / End Page

371 / 378

Location

United States

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Replicon
  • Macaca mulatta
  • Genetic Vectors
  • Genes, Viral
  • Encephalitis Virus, Venezuelan Equine
  • Cytotoxicity, Immunologic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, N. L., Caley, I. J., Brown, K. W., Betts, M. R., Irlbeck, D. M., McGrath, K. M., … Johnston, R. E. (2000). Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. J Virol, 74(1), 371–378. https://doi.org/10.1128/jvi.74.1.371-378.2000
Davis, N. L., I. J. Caley, K. W. Brown, M. R. Betts, D. M. Irlbeck, K. M. McGrath, M. J. Connell, et al. “Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles.J Virol 74, no. 1 (January 2000): 371–78. https://doi.org/10.1128/jvi.74.1.371-378.2000.
Davis NL, Caley IJ, Brown KW, Betts MR, Irlbeck DM, McGrath KM, et al. Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. J Virol. 2000 Jan;74(1):371–8.
Davis, N. L., et al. “Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles.J Virol, vol. 74, no. 1, Jan. 2000, pp. 371–78. Pubmed, doi:10.1128/jvi.74.1.371-378.2000.
Davis NL, Caley IJ, Brown KW, Betts MR, Irlbeck DM, McGrath KM, Connell MJ, Montefiori DC, Frelinger JA, Swanstrom R, Johnson PR, Johnston RE. Vaccination of macaques against pathogenic simian immunodeficiency virus with Venezuelan equine encephalitis virus replicon particles. J Virol. 2000 Jan;74(1):371–378.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

January 2000

Volume

74

Issue

1

Start / End Page

371 / 378

Location

United States

Related Subject Headings

  • Virology
  • Vaccines, Synthetic
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Replicon
  • Macaca mulatta
  • Genetic Vectors
  • Genes, Viral
  • Encephalitis Virus, Venezuelan Equine
  • Cytotoxicity, Immunologic