Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations.

Journal Article (Journal Article)

Eight different protocols were compared for their ability to raise protection against immunodeficiency virus challenges in rhesus macaques. The most promising containment of challenge infections was achieved by intradermal DNA priming followed by recombinant fowl pox virus booster immunizations. This containment did not require neutralizing antibody and was active for a series of challenges ending with a highly virulent virus with a primary isolate envelope heterologous to the immunizing strain.

Full Text

Duke Authors

Cited Authors

  • Robinson, HL; Montefiori, DC; Johnson, RP; Manson, KH; Kalish, ML; Lifson, JD; Rizvi, TA; Lu, S; Hu, SL; Mazzara, GP; Panicali, DL; Herndon, JG; Glickman, R; Candido, MA; Lydy, SL; Wyand, MS; McClure, HM

Published Date

  • May 1999

Published In

Volume / Issue

  • 5 / 5

Start / End Page

  • 526 - 534

PubMed ID

  • 10229229

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/8406


  • eng

Conference Location

  • United States