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Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys.

Publication ,  Journal Article
Schmitz, JE; Lifton, MA; Reimann, KA; Montefiori, DC; Shen, L; Racz, P; Tenner-Racz, K; Ollert, MW; Forman, MA; Gelman, RS; Vogel, CW; Letvin, NL
Published in: AIDS Res Hum Retroviruses
January 20, 1999

Cobra venom factor (CVF)-induced consumption of complement proteins was used to investigate the role of complement in vivo in the immunopathogenesis of simian immunodeficiency virus of macaques (SIVmac) infection in rhesus monkeys. Repeated administration of CVF was shown to deplete complement to <5% of baseline hemolytic activity of serum complement for 10 days in a normal monkey. Three groups of SIVmac-infected animals were then evaluated: monkeys treated with CVF resulting in complement depletion from days -1 to 10 postinfection, monkeys treated with CVF resulting in complement depletion from days 10 to 21 postinfection, and control monkeys that received no CVF. CD8+ SIVmac-specific cytotoxic T lymphocyte (CTL) generation and CD4+ T lymphocyte depletion during primary infection were not affected by CVF treatment. Viral load, assessed by measurements of plasma p27gag antigen and viral RNA, was transiently higher during the first 4 weeks following infection in the CVF-treated monkeys and the subsequent clinical course in these treated animals was accelerated. These results suggest that complement proteins may participate in immune defense mechanisms that decrease virus replication following the initial burst of intense viremia during primary SIVmac infection. However, we cannot rule out that the observed increased virus replication was induced by immune activation resulting from the administration of a foreign antigen to these monkeys.

Duke Scholars

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

January 20, 1999

Volume

15

Issue

2

Start / End Page

195 / 202

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Viral Load
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Retroviridae Proteins
  • RNA, Viral
  • Macaca mulatta
 

Citation

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Chicago
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MLA
NLM
Schmitz, J. E., Lifton, M. A., Reimann, K. A., Montefiori, D. C., Shen, L., Racz, P., … Letvin, N. L. (1999). Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. AIDS Res Hum Retroviruses, 15(2), 195–202. https://doi.org/10.1089/088922299311619
Schmitz, J. E., M. A. Lifton, K. A. Reimann, D. C. Montefiori, L. Shen, P. Racz, K. Tenner-Racz, et al. “Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys.AIDS Res Hum Retroviruses 15, no. 2 (January 20, 1999): 195–202. https://doi.org/10.1089/088922299311619.
Schmitz JE, Lifton MA, Reimann KA, Montefiori DC, Shen L, Racz P, et al. Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):195–202.
Schmitz, J. E., et al. “Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys.AIDS Res Hum Retroviruses, vol. 15, no. 2, Jan. 1999, pp. 195–202. Pubmed, doi:10.1089/088922299311619.
Schmitz JE, Lifton MA, Reimann KA, Montefiori DC, Shen L, Racz P, Tenner-Racz K, Ollert MW, Forman MA, Gelman RS, Vogel CW, Letvin NL. Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. AIDS Res Hum Retroviruses. 1999 Jan 20;15(2):195–202.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

January 20, 1999

Volume

15

Issue

2

Start / End Page

195 / 202

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Viral Load
  • Time Factors
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Retroviridae Proteins
  • RNA, Viral
  • Macaca mulatta