Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.

Journal Article (Journal Article)

Three different deletion mutants of simian immunodeficiency virus (SIV) that vary in their levels of attenuation were tested for the ability to protect against mucosal challenge with pathogenic SIV. Four female rhesus monkeys were vaccinated by intravenous inoculation with SIVmac239Delta3, four with SIVmac239Delta3X, and four with SIVmac239Delta4. These three vaccine strains exhibit increasing levels of attenuation: Delta3 < Delta3X

Full Text

Duke Authors

Cited Authors

  • Johnson, RP; Lifson, JD; Czajak, SC; Cole, KS; Manson, KH; Glickman, R; Yang, J; Montefiori, DC; Montelaro, R; Wyand, MS; Desrosiers, RC

Published Date

  • June 1999

Published In

Volume / Issue

  • 73 / 6

Start / End Page

  • 4952 - 4961

PubMed ID

  • 10233957

Pubmed Central ID

  • PMC112539

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/JVI.73.6.4952-4961.1999

Language

  • eng

Conference Location

  • United States