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Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus.

Publication ,  Journal Article
Langlois, AJ; Desrosiers, RC; Lewis, MG; KewalRamani, VN; Littman, DR; Zhou, JY; Manson, K; Wyand, MS; Bolognesi, DP; Montefiori, DC
Published in: J Virol
August 1998

Infection with attenuated simian immunodeficiency virus (SIV) in rhesus macaques has been shown to raise antibodies capable of neutralizing an animal challenge stock of primary SIVmac251 in CEMx174 cells that correlate with resistance to infection after experimental challenge with this virulent virus (M. S. Wyand, K. H. Manson, M. Garcia-Moll, D. C. Montefiori, and R. C. Desrosiers, J. Virol. 70:3724-3733, 1996). Here we show that these neutralizing antibodies are not detected in human and rhesus peripheral blood mononuclear cells (PBMC). In addition, neutralization of primary SIVmac251 in human and rhesus PBMC was rarely detected with plasma samples from a similar group of animals that had been infected either with SIVmac239Deltanef for 1.5 years or with SIVmac239Delta3 for 3.2 years, although low-level neutralization was detected in CEMx174 cells. Potent neutralization was detected in CEMx174 cells when the latter plasma samples were assessed with laboratory-adapted SIVmac251. In contrast to primary SIVmac251, laboratory-adapted SIVmac251 did not replicate in human and rhesus PBMC despite its ability to utilize CCR5, Bonzo/STRL33, and BOB/gpr15 as coreceptors for virus entry. These results illustrate the importance of virus passage history and the choice of indicator cells for making assessments of neutralizing antibodies to lentiviruses such as SIV. They also demonstrate that primary SIVmac251 is less sensitive to neutralization in human and rhesus PBMC than it is in established cell lines. Results obtained in PBMC did not support a role for neutralizing antibodies as a mechanism of protection in animals immunized with attenuated SIV and challenged with primary SIVmac251.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 1998

Volume

72

Issue

8

Start / End Page

6950 / 6955

Location

United States

Related Subject Headings

  • Virology
  • Viral Vaccines
  • Vaccines, Attenuated
  • Vaccination
  • Tumor Cells, Cultured
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Neutralization Tests
  • Macaca mulatta
  • Humans
 

Citation

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ICMJE
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Langlois, A. J., Desrosiers, R. C., Lewis, M. G., KewalRamani, V. N., Littman, D. R., Zhou, J. Y., … Montefiori, D. C. (1998). Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. J Virol, 72(8), 6950–6955. https://doi.org/10.1128/JVI.72.8.6950-6955.1998
Langlois, A. J., R. C. Desrosiers, M. G. Lewis, V. N. KewalRamani, D. R. Littman, J. Y. Zhou, K. Manson, M. S. Wyand, D. P. Bolognesi, and D. C. Montefiori. “Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus.J Virol 72, no. 8 (August 1998): 6950–55. https://doi.org/10.1128/JVI.72.8.6950-6955.1998.
Langlois AJ, Desrosiers RC, Lewis MG, KewalRamani VN, Littman DR, Zhou JY, et al. Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. J Virol. 1998 Aug;72(8):6950–5.
Langlois, A. J., et al. “Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus.J Virol, vol. 72, no. 8, Aug. 1998, pp. 6950–55. Pubmed, doi:10.1128/JVI.72.8.6950-6955.1998.
Langlois AJ, Desrosiers RC, Lewis MG, KewalRamani VN, Littman DR, Zhou JY, Manson K, Wyand MS, Bolognesi DP, Montefiori DC. Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus. J Virol. 1998 Aug;72(8):6950–6955.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

August 1998

Volume

72

Issue

8

Start / End Page

6950 / 6955

Location

United States

Related Subject Headings

  • Virology
  • Viral Vaccines
  • Vaccines, Attenuated
  • Vaccination
  • Tumor Cells, Cultured
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Neutralization Tests
  • Macaca mulatta
  • Humans