Skip to main content
Journal cover image

Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.

Publication ,  Journal Article
Lewis, MG; Elkins, WR; McCutchan, FE; Benveniste, RE; Lai, CY; Montefiori, DC; Burke, DS; Eddy, GA; Shafferman, A
Published in: Vaccine
October 1993

Inactivated plasma collected from either SIV-infected or peptide-vaccinated macaques was transferred into 17 naive rhesus monkeys. Two additional macaques received normal plasma and served as controls. Following transfer all 19 monkeys were inoculated with SIV. While the controls became infected and were virus-isolation-positive, 3 of 6 recipients of SIV peptide vaccine plasma and 9 of 11 recipients of SIV-infected monkey plasma were protected. None of the 12 protected animals became virus-isolation-positive or seroconverted within 100 days of follow-up. One, however was SIV-PCR-positive. All 12 protected animals were rechallenged 100 days after the initial inoculation; 8 became infected and yielded virus as expected, but 4 remained uninfected. One of the latter was the SIV-PCR-positive monkey mentioned above, suggesting that cryptic SIV infection may be of significance in immunological protection. The results demonstrate that envelope anti-peptide antibodies have similar protective potential in vivo as antibodies directed to the whole virus. In vitro neutralization competition assays performed with sera from vaccinated macaques in the presence of the free peptides suggest that of the four conserved envelope peptides of the vaccine, the two originating from gp41 rather than the two from gp120 are responsible for inducing the neutralizing anti-syncytial activity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

October 1993

Volume

11

Issue

13

Start / End Page

1347 / 1355

Location

Netherlands

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Peptide Fragments
  • Molecular Sequence Data
  • Membrane Glycoproteins
  • Macaca mulatta
  • Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, M. G., Elkins, W. R., McCutchan, F. E., Benveniste, R. E., Lai, C. Y., Montefiori, D. C., … Shafferman, A. (1993). Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. Vaccine, 11(13), 1347–1355. https://doi.org/10.1016/0264-410x(93)90106-8
Lewis, M. G., W. R. Elkins, F. E. McCutchan, R. E. Benveniste, C. Y. Lai, D. C. Montefiori, D. S. Burke, G. A. Eddy, and A. Shafferman. “Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.Vaccine 11, no. 13 (October 1993): 1347–55. https://doi.org/10.1016/0264-410x(93)90106-8.
Lewis MG, Elkins WR, McCutchan FE, Benveniste RE, Lai CY, Montefiori DC, et al. Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. Vaccine. 1993 Oct;11(13):1347–55.
Lewis, M. G., et al. “Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection.Vaccine, vol. 11, no. 13, Oct. 1993, pp. 1347–55. Pubmed, doi:10.1016/0264-410x(93)90106-8.
Lewis MG, Elkins WR, McCutchan FE, Benveniste RE, Lai CY, Montefiori DC, Burke DS, Eddy GA, Shafferman A. Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. Vaccine. 1993 Oct;11(13):1347–1355.
Journal cover image

Published In

Vaccine

DOI

ISSN

0264-410X

Publication Date

October 1993

Volume

11

Issue

13

Start / End Page

1347 / 1355

Location

Netherlands

Related Subject Headings

  • Virology
  • Viral Envelope Proteins
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Peptide Fragments
  • Molecular Sequence Data
  • Membrane Glycoproteins
  • Macaca mulatta
  • Lymphocytes