Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol.

Journal Article (Journal Article)

The antiseptics 4% chlorhexidine gluconate detergent formulation containing 4% isopropyl alcohol (Hibiclens/Hibiscrub) and 0.5% chlorhexidine gluconate in 70% isopropyl alcohol with emollients (Hibistat/Hibisol) efficiently inactivated human immunodeficiency virus (HIV) produced in cell culture within 15 seconds. These antiseptics were completely effective at 1:100 and 1:5 dilutions, respectively. Therefore, use of these products according to the manufacturer's instructions (i.e. undiluted) for routine disinfection of hands following contact with HIV-contaminated materials, as well as immediate disinfection of abrasions or cuts exposed to HIV, should have significant protective effects.

Full Text

Duke Authors

Cited Authors

  • Montefiori, DC; Robinson, WE; Modliszewski, A; Mitchell, WM

Published Date

  • April 1990

Published In

Volume / Issue

  • 15 / 3

Start / End Page

  • 279 - 282

PubMed ID

  • 1971635

International Standard Serial Number (ISSN)

  • 0195-6701

Digital Object Identifier (DOI)

  • 10.1016/0195-6701(90)90036-n


  • eng

Conference Location

  • England