Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol.
Publication
, Journal Article
Montefiori, DC; Robinson, WE; Modliszewski, A; Mitchell, WM
Published in: J Hosp Infect
April 1990
The antiseptics 4% chlorhexidine gluconate detergent formulation containing 4% isopropyl alcohol (Hibiclens/Hibiscrub) and 0.5% chlorhexidine gluconate in 70% isopropyl alcohol with emollients (Hibistat/Hibisol) efficiently inactivated human immunodeficiency virus (HIV) produced in cell culture within 15 seconds. These antiseptics were completely effective at 1:100 and 1:5 dilutions, respectively. Therefore, use of these products according to the manufacturer's instructions (i.e. undiluted) for routine disinfection of hands following contact with HIV-contaminated materials, as well as immediate disinfection of abrasions or cuts exposed to HIV, should have significant protective effects.
Duke Scholars
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Published In
J Hosp Infect
DOI
ISSN
0195-6701
Publication Date
April 1990
Volume
15
Issue
3
Start / End Page
279 / 282
Location
England
Related Subject Headings
- T-Lymphocytes
- Surface-Active Agents
- Humans
- Human T-lymphotropic virus 2
- HIV-1
- Epidemiology
- Detergents
- Chlorhexidine
- Cell Line, Transformed
- Antisepsis
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ICMJE
MLA
NLM
Montefiori, D. C., Robinson, W. E., Modliszewski, A., & Mitchell, W. M. (1990). Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol. J Hosp Infect, 15(3), 279–282. https://doi.org/10.1016/0195-6701(90)90036-n
Montefiori, D. C., W. E. Robinson, A. Modliszewski, and W. M. Mitchell. “Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol.” J Hosp Infect 15, no. 3 (April 1990): 279–82. https://doi.org/10.1016/0195-6701(90)90036-n.
Montefiori DC, Robinson WE, Modliszewski A, Mitchell WM. Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol. J Hosp Infect. 1990 Apr;15(3):279–82.
Montefiori, D. C., et al. “Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol.” J Hosp Infect, vol. 15, no. 3, Apr. 1990, pp. 279–82. Pubmed, doi:10.1016/0195-6701(90)90036-n.
Montefiori DC, Robinson WE, Modliszewski A, Mitchell WM. Effective inactivation of human immunodeficiency virus with chlorhexidine antiseptics containing detergents and alcohol. J Hosp Infect. 1990 Apr;15(3):279–282.
Published In
J Hosp Infect
DOI
ISSN
0195-6701
Publication Date
April 1990
Volume
15
Issue
3
Start / End Page
279 / 282
Location
England
Related Subject Headings
- T-Lymphocytes
- Surface-Active Agents
- Humans
- Human T-lymphotropic virus 2
- HIV-1
- Epidemiology
- Detergents
- Chlorhexidine
- Cell Line, Transformed
- Antisepsis