Regulatory role of glucose transport and phosphorylation in pancreatic islet β-cells
Insulin secretion is largely controlled by the level of circulating glucose. The mechanism by which glucose stimulates insulin release from pancreatic islet β-cells has been an important but difficult area of investigation. In recent years, the tools of molecular biology have been applied to test a concept previously developed from physiological studies that glucose transport and phosphorylation represent key regulatory steps for glucose-stimulated insulin secretion. This article summarizes the recent molecular studies, deals with controversial issues that have arisen in the area, and highlights the role of defects in glucose transport and phosphorylation in certain forms of diabetes.