Glucose-stimulated insulin secretion in cell lines


Journal Article

Because islet β-cells are expensive and difficult to isolate, islet transplantation may have limited applicability for insulin replacement in insulin-dependent diabetes mellitus. Knowledge of glucose sensing guides the development of clonal cell lines that behave Like β-cells. High-K(m) glucose transport and glucose phosphorylation both contribute to glucose-stimulated insulin secretion in clonal cells and β-cells. Introduction of these and other key molecular components of the β-cell into clonal lines may eventually result in glucose-responsive, insulin-secreting cell implants for human use.

Duke Authors

Cited Authors

  • Cassidy, LE; Newgard, CB

Published Date

  • December 1, 1994

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 189 - 195

International Standard Serial Number (ISSN)

  • 0394-3402

Citation Source

  • Scopus