The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx.

Journal Article (Journal Article)

PURPOSE: Pretreatment CT volumetric measurement of the primary tumor has been shown to be a predictor of local control in patients with laryngeal carcinoma treated with radiation therapy (RT) alone. A direct association has been demonstrated between tumor volume of supraglottic squamous cell carcinoma (SGSCCA) and local control. However, the association between tumor volume of SGSCCA and local control has not been investigated in patients treated surgically. The purpose of this study was to determine the relationship between SGSCCA tumor volume and local control in patients treated surgically. MATERIALS AND METHODS: Primary site tumor volume was calculated from pretreatment CT studies in 37 laryngeal supraglottic carcinomas treated surgically. All patients had clinical follow-up for evidence of recurrent tumor along the surgical margins at the primary site for a minimum of 2 years after completion of treatment. Statistical analysis consisted of Mantel-Haenszel chi-square tests and Fisher's exact test. RESULTS: Overall local control rate was 92% (33 of 37). Tumor volume was significantly associated with local control (p <. 05). Local control rate for tumors with volumes <16 cc was 94% (32 of 34) (p <.05). CONCLUSIONS: Pretreatment CT volumetric analysis is useful for predicting local control in patients with SGSCCA carcinoma treated surgically.

Full Text

Duke Authors

Cited Authors

  • Mukherji, SK; O'Brien, SM; Gerstle, RJ; Weissler, M; Shockley, W; Stone, JA; Castillo, M

Published Date

  • May 2000

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 282 - 287

PubMed ID

  • 10748452

International Standard Serial Number (ISSN)

  • 1043-3074

Digital Object Identifier (DOI)

  • 10.1002/(sici)1097-0347(200005)22:3<282::aid-hed11>;2-k


  • eng

Conference Location

  • United States