Prospective phase I trial of conservative management of low rectal lesions.

Journal Article (Journal Article)

The purpose of this study was to assess and function and to compare the morbidity of local excision and postoperative radiotherapy for rectal adenocarcinoma with the morbidity of abdominoperineal resection. A posterior parasacral approach was used for local excision. All patients had negative margins, and all but one were continent after completion of radiotherapy. Seven patients (29%) had either a wound infection or a fistula in the local excision group. No local failures occurred, although follow-up was only 13 months. Thirteen (50%) of the 26 patients who underwent an abdominoperineal resection developed at least one complication. Combined treatment that spares the rectal sphincters may be preferable in selected patients with low rectal cancer, if long-term disease-free survival is maintained.

Full Text

Duke Authors

Cited Authors

  • McCready, DR; Ota, DM; Rich, TA; Thielvoldt, D; Jessup, JM

Published Date

  • January 1989

Published In

Volume / Issue

  • 124 / 1

Start / End Page

  • 67 - 70

PubMed ID

  • 2910250

International Standard Serial Number (ISSN)

  • 0004-0010

Digital Object Identifier (DOI)

  • 10.1001/archsurg.1989.01410010077016


  • eng

Conference Location

  • United States