Clinical significance of anti human leukocyte antigen antibodies in lung transplantation
The response to allogenic solid organ transplant appears complex, involving both cellular and humoral components. Emerging evidence supports a pathogenic role for antibody to donor human leukocyte antigen in the development of chronic lung transplant rejection. Additional research is needed to better understand mechanisms of antibody production, further describe cellular effects of antibody-ligand interactions, and, importantly, explain why anti human leukocyte antigen antibody is detectable in only a subset of patients with bronchiolitis obliterans syndrome. © 2003 Lippincott Williams & Wilkins.
Palmer, SM; Garantziotis, S; Reinsmoen, NL
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