Spantide: failure to antagonize bombesin-induced stimulation of gastrin secretion in dogs.

Other Article (Journal Article)

Spantide ([d-Arg1, d-Trp7,9, Leu11] substance P) was shown to function not only as a substance P receptor antagonist but also as a bombesin receptor antagonist. This study examined the effects of spantide on intravenous bombesin-induced stimulation of gastrin and acid secretion. Dogs were infused with spantide (1 or 10 nmol kg 1 hr 1) or saline and bombesin (60 pmol kg-1 hr-1), and the gastric acid and plasma gastrin responses were monitored. Spantide did not significantly modify gastrin or gastric acid secretion induced by bombesin. It is concluded that spantide may not be a useful bombesin antagonist for in vivo studies.

Full Text

Duke Authors

Cited Authors

  • Pappas, T; Hamel, D; Debas, H; Walsh, J; Tache, Y

Published Date

  • September 1985

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 1001 - 1003

PubMed ID

  • 2417201

International Standard Serial Number (ISSN)

  • 0196-9781

Digital Object Identifier (DOI)

  • 10.1016/0196-9781(85)90335-3


  • eng

Conference Location

  • United States