Corticotropin-releasing factor inhibits gastric emptying in dogs.

Journal Article (Journal Article)

The purpose of the present study was to evaluate the effect of ovine corticotropin-releasing factor (CRF) on the gastric emptying of a saline meal in conscious dogs. Intravenous infusion of CRF (220-880 pmol . kg-1 . h-1), induced a significant linear dose dependent inhibition of gastric emptying (16-71%). CRF action was not modified by naloxone and not associated with vomiting or other side effects. Intravenous infusion of sulfated cholecystokinin octapeptide (CCK-8, 50-200 pmol . kg-1 . h-1) inhibited gastric emptying by 29-52%. The relative potency of CRF with respect to CCK-8 is 4 times less. These studies demonstrated that CRF given intravenously in picomolar amount inhibits gastric emptying of a liquid meal in dogs through a mechanism unrelated to opiates. The role of endogenous CRF in stress-induced inhibition of gastric emptying needs to be investigated.

Full Text

Duke Authors

Cited Authors

  • Pappas, T; Debas, H; Taché, Y

Published Date

  • July 1985

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 193 - 199

PubMed ID

  • 3877318

International Standard Serial Number (ISSN)

  • 0167-0115

Digital Object Identifier (DOI)

  • 10.1016/0167-0115(85)90050-3


  • eng

Conference Location

  • Netherlands