Treatment of non-Aspergillus moulds in immunocompromised patients, with amphotericin B lipid complex.

Published

Journal Article

An assessment was made of the efficacy and renal safety of amphotericin B lipid complex (ABLC) in the treatment of patients with invasive fungal infections caused by moulds other than Aspergillus species, on the basis of a retrospective analysis of data from the Collaborative Exchange of Antifungal Research (CLEAR) database. Data from CLEAR for 64 patients with zygomycosis were published previously. The database was further queried and yielded results for 28 patients with fusariosis and 84 patients infected with other non-Aspergillus moulds. Of 26 patients with fusariosis whose results could be evaluated, 46% (n = 12) were cured or improved, and an additional 12% (n = 3) were stable. Of 79 patients infected with other non-Aspergillus moulds whose results could be evaluated, 61% (n = 48) were cured or improved, and an additional 15% (n = 12) were stable. In an area with little guidance for therapy, the CLEAR data indicate that ABLC can be an effective broad-spectrum treatment choice for several invasive and refractory non-Aspergillus mould infections.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR

Published Date

  • May 1, 2005

Published In

Volume / Issue

  • 40 Suppl 6 /

Start / End Page

  • S401 - S408

PubMed ID

  • 15809926

Pubmed Central ID

  • 15809926

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/429331

Language

  • eng

Conference Location

  • United States