Fungal virulence genes as targets for antifungal chemotherapy.
Journal Article (Review)
Fungal virulence genes have now met the age of molecular pathogenesis. The definition of virulence genes needs to be broad so that it encompasses the focus on molecular antifungal targets and vaccine epitopes. However, in the broad but simple definition of a virulence gene, there will be many complex genetic and host interactions which investigators will need to carefully define. Nevertheless, with the increasing numbers of serious fungal infections produced by old and newly reported organisms, the paucity of present antifungal drugs, and the likelihood of increasing drug resistance, the need for investigations into understanding fungal virulence at the molecular level has never been more important.
Full Text
Duke Authors
Cited Authors
- Perfect, JR
Published Date
- July 1996
Published In
Volume / Issue
- 40 / 7
Start / End Page
- 1577 - 1583
PubMed ID
- 8807043
Pubmed Central ID
- 8807043
International Standard Serial Number (ISSN)
- 0066-4804
Digital Object Identifier (DOI)
- 10.1128/AAC.40.7.1577
Language
- eng
Conference Location
- United States