Fungal virulence genes as targets for antifungal chemotherapy.

Journal Article (Review)

Fungal virulence genes have now met the age of molecular pathogenesis. The definition of virulence genes needs to be broad so that it encompasses the focus on molecular antifungal targets and vaccine epitopes. However, in the broad but simple definition of a virulence gene, there will be many complex genetic and host interactions which investigators will need to carefully define. Nevertheless, with the increasing numbers of serious fungal infections produced by old and newly reported organisms, the paucity of present antifungal drugs, and the likelihood of increasing drug resistance, the need for investigations into understanding fungal virulence at the molecular level has never been more important.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR

Published Date

  • July 1996

Published In

Volume / Issue

  • 40 / 7

Start / End Page

  • 1577 - 1583

PubMed ID

  • 8807043

Pubmed Central ID

  • 8807043

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.40.7.1577


  • eng

Conference Location

  • United States