Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.


Journal Article

Cerebrospinal fluid from rabbits with chronic cryptococcal meningitis was tested for its chemotactic activity towards polymorphonuclear cells and monocytes. CSF chemotactic activity was present; it peaked 5-8 days after infection, coinciding with the time when the number of inflammatory cells in CSF was greatest. However, little chemotactic activity could be found in the early stages of infection, during the initial ingress of inflammatory cells. The chemotactic activity appeared to be host-derived, with characteristics consistent with lymphokine(s) or C5a. Treatment with cortisone significantly reduced the CSF chemotactic activity for both cell types; this reduction may contribute to the severe CSF leukopenia observed in cortisone-treated animals, which are unable to eradicate this yeast infection. Modulation of CSF chemotactic activity may be important to the success or failure of the host central nervous system response to Cryptococcus neoformans.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Durack, DT

Published Date

  • February 1985

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 37 - 45

PubMed ID

  • 3992427

Pubmed Central ID

  • 3992427

International Standard Serial Number (ISSN)

  • 0036-2174

Digital Object Identifier (DOI)

  • 10.1080/00362178585380071


  • eng

Conference Location

  • England