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Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.

Publication ,  Journal Article
Perfect, JR; Durack, DT
Published in: Sabouraudia
February 1985

Cerebrospinal fluid from rabbits with chronic cryptococcal meningitis was tested for its chemotactic activity towards polymorphonuclear cells and monocytes. CSF chemotactic activity was present; it peaked 5-8 days after infection, coinciding with the time when the number of inflammatory cells in CSF was greatest. However, little chemotactic activity could be found in the early stages of infection, during the initial ingress of inflammatory cells. The chemotactic activity appeared to be host-derived, with characteristics consistent with lymphokine(s) or C5a. Treatment with cortisone significantly reduced the CSF chemotactic activity for both cell types; this reduction may contribute to the severe CSF leukopenia observed in cortisone-treated animals, which are unable to eradicate this yeast infection. Modulation of CSF chemotactic activity may be important to the success or failure of the host central nervous system response to Cryptococcus neoformans.

Duke Scholars

Published In

Sabouraudia

DOI

ISSN

0036-2174

Publication Date

February 1985

Volume

23

Issue

1

Start / End Page

37 / 45

Location

England

Related Subject Headings

  • Rabbits
  • Neutrophils
  • Monocytes
  • Meningitis
  • Leukopenia
  • Cryptococcosis
  • Cortisone
  • Chemotaxis, Leukocyte
  • Chemotactic Factors
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Perfect, J. R., & Durack, D. T. (1985). Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis. Sabouraudia, 23(1), 37–45. https://doi.org/10.1080/00362178585380071
Perfect, J. R., and D. T. Durack. “Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.Sabouraudia 23, no. 1 (February 1985): 37–45. https://doi.org/10.1080/00362178585380071.
Perfect JR, Durack DT. Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis. Sabouraudia. 1985 Feb;23(1):37–45.
Perfect, J. R., and D. T. Durack. “Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis.Sabouraudia, vol. 23, no. 1, Feb. 1985, pp. 37–45. Pubmed, doi:10.1080/00362178585380071.
Perfect JR, Durack DT. Chemotactic activity of cerebrospinal fluid in experimental cryptococcal meningitis. Sabouraudia. 1985 Feb;23(1):37–45.

Published In

Sabouraudia

DOI

ISSN

0036-2174

Publication Date

February 1985

Volume

23

Issue

1

Start / End Page

37 / 45

Location

England

Related Subject Headings

  • Rabbits
  • Neutrophils
  • Monocytes
  • Meningitis
  • Leukopenia
  • Cryptococcosis
  • Cortisone
  • Chemotaxis, Leukocyte
  • Chemotactic Factors
  • Animals