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Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.

Publication ,  Journal Article
Perfect, JR; Savani, DV; Durack, DT
Published in: Antimicrob Agents Chemother
April 1986

Itraconazole and fluconazole, two new triazoles, were examined for their antifungal activity in rabbits. Fluconazole easily crossed the blood-cerebrospinal fluid barrier, and active drug was eliminated in high concentrations in the urine. On the other hand, itraconazole did not cross the blood-cerebrospinal fluid barrier in measurable amounts, and urine concentrations were variable. Despite differences in pharmacokinetics at the site of infection, both agents were equally effective in treating cryptococcal meningitis and candida pyelonephritis in animals. By using a ketoconazole-resistant strain of Candida albicans, we showed that there was cross-resistance in vivo between these two new triazole compounds.

Duke Scholars

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 1986

Volume

29

Issue

4

Start / End Page

579 / 583

Location

United States

Related Subject Headings

  • Triazoles
  • Rabbits
  • Pyelonephritis
  • Microbiology
  • Meningitis
  • Ketoconazole
  • Itraconazole
  • Immunity
  • Fluconazole
  • Dose-Response Relationship, Drug
 

Citation

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Perfect, J. R., Savani, D. V., & Durack, D. T. (1986). Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother, 29(4), 579–583. https://doi.org/10.1128/AAC.29.4.579
Perfect, J. R., D. V. Savani, and D. T. Durack. “Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.Antimicrob Agents Chemother 29, no. 4 (April 1986): 579–83. https://doi.org/10.1128/AAC.29.4.579.
Perfect JR, Savani DV, Durack DT. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother. 1986 Apr;29(4):579–83.
Perfect, J. R., et al. “Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.Antimicrob Agents Chemother, vol. 29, no. 4, Apr. 1986, pp. 579–83. Pubmed, doi:10.1128/AAC.29.4.579.
Perfect JR, Savani DV, Durack DT. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother. 1986 Apr;29(4):579–583.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 1986

Volume

29

Issue

4

Start / End Page

579 / 583

Location

United States

Related Subject Headings

  • Triazoles
  • Rabbits
  • Pyelonephritis
  • Microbiology
  • Meningitis
  • Ketoconazole
  • Itraconazole
  • Immunity
  • Fluconazole
  • Dose-Response Relationship, Drug