Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.

Journal Article (Journal Article)

Itraconazole and fluconazole, two new triazoles, were examined for their antifungal activity in rabbits. Fluconazole easily crossed the blood-cerebrospinal fluid barrier, and active drug was eliminated in high concentrations in the urine. On the other hand, itraconazole did not cross the blood-cerebrospinal fluid barrier in measurable amounts, and urine concentrations were variable. Despite differences in pharmacokinetics at the site of infection, both agents were equally effective in treating cryptococcal meningitis and candida pyelonephritis in animals. By using a ketoconazole-resistant strain of Candida albicans, we showed that there was cross-resistance in vivo between these two new triazole compounds.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Savani, DV; Durack, DT

Published Date

  • April 1986

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 579 - 583

PubMed ID

  • 3010846

Pubmed Central ID

  • PMC180445

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.29.4.579


  • eng

Conference Location

  • United States