Penetration of imidazoles and triazoles into cerebrospinal fluid of rabbits.

Published

Journal Article

We studied the penetration of two imidazoles (ketoconazole and vibunazole) and two triazoles (itraconazole and UK-49,858) into cerebrospinal fluid (CSF) of rabbits with and without meningitis. There were wide differences in degree of penetration of these drugs into CSF, from less than 3% to 66% of simultaneous serum concentrations. UK-49,858, which has little protein-binding, penetrated freely while itraconazole, which is highly protein-bound, could not be detected in CSF. Intermediate concentrations of vibunazole and ketoconazole were found in CSF. Presence of meningeal inflammation modestly increased CSF concentrations of ketoconazole but had no significant effect on penetration of the other three drugs. The excellent penetration of UK-49,858 indicates that it has promise for treatment of CNS fungal infections.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Durack, DT

Published Date

  • July 1, 1985

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 81 - 86

PubMed ID

  • 2995303

Pubmed Central ID

  • 2995303

Electronic International Standard Serial Number (EISSN)

  • 1460-2091

International Standard Serial Number (ISSN)

  • 0305-7453

Digital Object Identifier (DOI)

  • 10.1093/jac/16.1.81

Language

  • eng