Effects of cyclosporine in experimental cryptococcal meningitis.

Journal Article (Journal Article)

We studied the effects of cyclosporine on experimental cryptococcal meningitis. Like cortisone, cyclosporine depressed the highly effective defense mechanisms of normal rabbits against inoculated Cryptococcus neoformans, causing them to develop progressive, fatal cryptococcal meningitis. Unlike cortisone, which causes a striking reduction in leukocytes in cerebrospinal fluid, cyclosporine depressed mononuclear cell function rather than numbers. Interleukin 2, a primary target for the immunodepressive action of cyclosporine, appears to be of central importance in central nervous system defenses against cryptococci. The findings suggest that humans receiving cyclosporine are likely to suffer increased incidence of cryptococcal infection.

Full Text

Duke Authors

Cited Authors

  • Perfect, JR; Durack, DT

Published Date

  • October 1985

Published In

Volume / Issue

  • 50 / 1

Start / End Page

  • 22 - 26

PubMed ID

  • 3899932

Pubmed Central ID

  • PMC262129

International Standard Serial Number (ISSN)

  • 0019-9567

Digital Object Identifier (DOI)

  • 10.1128/iai.50.1.22-26.1985


  • eng

Conference Location

  • United States