Effects of cyclosporine in experimental cryptococcal meningitis.
Publication
, Journal Article
Perfect, JR; Durack, DT
Published in: Infect Immun
October 1985
We studied the effects of cyclosporine on experimental cryptococcal meningitis. Like cortisone, cyclosporine depressed the highly effective defense mechanisms of normal rabbits against inoculated Cryptococcus neoformans, causing them to develop progressive, fatal cryptococcal meningitis. Unlike cortisone, which causes a striking reduction in leukocytes in cerebrospinal fluid, cyclosporine depressed mononuclear cell function rather than numbers. Interleukin 2, a primary target for the immunodepressive action of cyclosporine, appears to be of central importance in central nervous system defenses against cryptococci. The findings suggest that humans receiving cyclosporine are likely to suffer increased incidence of cryptococcal infection.
Duke Scholars
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
October 1985
Volume
50
Issue
1
Start / End Page
22 / 26
Location
United States
Related Subject Headings
- T-Lymphocytes
- Rabbits
- Microbiology
- Meningitis
- Lymphocytes, Null
- Lymphocyte Activation
- Immunosuppression Therapy
- Immunity, Cellular
- Cyclosporins
- Cryptococcus neoformans
Citation
APA
Chicago
ICMJE
MLA
NLM
Perfect, J. R., & Durack, D. T. (1985). Effects of cyclosporine in experimental cryptococcal meningitis. Infect Immun, 50(1), 22–26. https://doi.org/10.1128/iai.50.1.22-26.1985
Perfect, J. R., and D. T. Durack. “Effects of cyclosporine in experimental cryptococcal meningitis.” Infect Immun 50, no. 1 (October 1985): 22–26. https://doi.org/10.1128/iai.50.1.22-26.1985.
Perfect JR, Durack DT. Effects of cyclosporine in experimental cryptococcal meningitis. Infect Immun. 1985 Oct;50(1):22–6.
Perfect, J. R., and D. T. Durack. “Effects of cyclosporine in experimental cryptococcal meningitis.” Infect Immun, vol. 50, no. 1, Oct. 1985, pp. 22–26. Pubmed, doi:10.1128/iai.50.1.22-26.1985.
Perfect JR, Durack DT. Effects of cyclosporine in experimental cryptococcal meningitis. Infect Immun. 1985 Oct;50(1):22–26.
Published In
Infect Immun
DOI
ISSN
0019-9567
Publication Date
October 1985
Volume
50
Issue
1
Start / End Page
22 / 26
Location
United States
Related Subject Headings
- T-Lymphocytes
- Rabbits
- Microbiology
- Meningitis
- Lymphocytes, Null
- Lymphocyte Activation
- Immunosuppression Therapy
- Immunity, Cellular
- Cyclosporins
- Cryptococcus neoformans