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Cryptococcemia.

Publication ,  Journal Article
Perfect, JR; Durack, DT; Gallis, HA
Published in: Medicine (Baltimore)
March 1983

Previous reports have emphasized that cryptococcemia is almost uniformly fatal. To define the clinical course and prognostic and therapeutic implications of cryptococcemia, we studied 15 patients treated at this medical center over the past 7 years. Cryptococcemia was strongly associated with corticosteroid therapy, especially when the dosage had recently been increased. Meningitis was common (but not invariably present) in these patients, characteristically with a large burden of organisms in the cerebrospinal fluid. Cryptococcemia developed during hospitalization in one-third of our patients; this high rate of nosocomial infection emphasizes that C. neoformans infection should be considered in febrile, immunocompromised patients even when the initial work-up is negative. Most of these patients were treated with amphotericin B plus 5-fluorocytosine. Although the one-year survival rate of 4/15 (29%) was dismal, no patient died from uncontrolled cryptococcal infection. Other infections, which developed before, during or after cryptococcemia was diagnosed, were the major immediate cause of morbidity and mortality. The progress of underlying diseases and the outcome of concomitant infections in these patients were more important determinants of survival than was cryptococcemia itself.

Duke Scholars

Published In

Medicine (Baltimore)

DOI

ISSN

0025-7974

Publication Date

March 1983

Volume

62

Issue

2

Start / End Page

98 / 109

Location

United States

Related Subject Headings

  • Prognosis
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Host-Parasite Interactions
  • Flucytosine
  • Female
  • Cryptococcus neoformans
  • Cryptococcosis
 

Citation

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ICMJE
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Perfect, J. R., Durack, D. T., & Gallis, H. A. (1983). Cryptococcemia. Medicine (Baltimore), 62(2), 98–109. https://doi.org/10.1097/00005792-198303000-00003
Perfect, J. R., D. T. Durack, and H. A. Gallis. “Cryptococcemia.Medicine (Baltimore) 62, no. 2 (March 1983): 98–109. https://doi.org/10.1097/00005792-198303000-00003.
Perfect JR, Durack DT, Gallis HA. Cryptococcemia. Medicine (Baltimore). 1983 Mar;62(2):98–109.
Perfect, J. R., et al. “Cryptococcemia.Medicine (Baltimore), vol. 62, no. 2, Mar. 1983, pp. 98–109. Pubmed, doi:10.1097/00005792-198303000-00003.
Perfect JR, Durack DT, Gallis HA. Cryptococcemia. Medicine (Baltimore). 1983 Mar;62(2):98–109.

Published In

Medicine (Baltimore)

DOI

ISSN

0025-7974

Publication Date

March 1983

Volume

62

Issue

2

Start / End Page

98 / 109

Location

United States

Related Subject Headings

  • Prognosis
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Host-Parasite Interactions
  • Flucytosine
  • Female
  • Cryptococcus neoformans
  • Cryptococcosis