Influence of agglutinating antibody in experimental cryptococcal meningitis.
Journal Article (Journal Article)
A model for chronic Cryptococcus neoformans meningitis in corticosteroid-treated rabbits was used to determine the influence of pre-formed agglutinating antibody to cryptococcal polysaccharide on the progress of this infection. Immunized rabbits developed serum agglutinating antibody with a geometric mean titre of 1:32, but none was detected in cerebrospinal fluid. Prior immunization did not enhance immunity to infection, had no effect on the number of viable cryptococci in cerebrospinal fluid, and did not prevent dissemination outside the central nervous system. Future investigations in this field should focus on cellular rather than humoral defence mechanisms.
Full Text
Duke Authors
Cited Authors
- Perfect, JR; Lang, SD; Durack, DT
Published Date
- December 1, 1981
Published In
Volume / Issue
- 62 / 6
Start / End Page
- 595 - 599
PubMed ID
- 7034765
Pubmed Central ID
- PMC2041737
International Standard Serial Number (ISSN)
- 0007-1021
Language
- eng
Conference Location
- England