Potential value of cefoperazone in bacterial meningitis: experimental studies.


Journal Article

To assess the potential value of cefoperazone in treating bacterial meningitis, its pharmacokinetics in the cerebrospinal fluid of rabbits were studied. Cefoperazone penetrated poorly into the cerebrospinal fluid of rabbits with uninflamed meninges, but in the presence of meningitis concentrations increased 2- to 3-fold. These concentrations were above the minimum inhibitory concentrations for the majority of Enterobacteriaceae, indicating the potential value of cefoperazone in treating bacterial meningitis. The half-lives of cefoperazone and moxalactam in cerebrospinal fluid, measured by a bioassay, were marked prolonged by meningeal inflammation. In contrast, the half-life of cefotaxime in cerebrospinal fluid was short. Consequently both cefoperazone and moxalactam provided significantly better antibacterial effect in cerebrospinal fluid than did cefotaxime.

Full Text

Duke Authors

Cited Authors

  • Durack, DT; Perfect, JR

Published Date

  • 1981

Published In

Volume / Issue

  • 22 Suppl 1 /

Start / End Page

  • 60 - 64

PubMed ID

  • 6269824

Pubmed Central ID

  • 6269824

International Standard Serial Number (ISSN)

  • 0012-6667

Digital Object Identifier (DOI)

  • 10.2165/00003495-198100221-00013


  • eng

Conference Location

  • New Zealand