Skip to main content
Journal cover image

Potential value of cefoperazone in bacterial meningitis: experimental studies.

Publication ,  Journal Article
Durack, DT; Perfect, JR
Published in: Drugs
1981

To assess the potential value of cefoperazone in treating bacterial meningitis, its pharmacokinetics in the cerebrospinal fluid of rabbits were studied. Cefoperazone penetrated poorly into the cerebrospinal fluid of rabbits with uninflamed meninges, but in the presence of meningitis concentrations increased 2- to 3-fold. These concentrations were above the minimum inhibitory concentrations for the majority of Enterobacteriaceae, indicating the potential value of cefoperazone in treating bacterial meningitis. The half-lives of cefoperazone and moxalactam in cerebrospinal fluid, measured by a bioassay, were marked prolonged by meningeal inflammation. In contrast, the half-life of cefotaxime in cerebrospinal fluid was short. Consequently both cefoperazone and moxalactam provided significantly better antibacterial effect in cerebrospinal fluid than did cefotaxime.

Duke Scholars

Published In

Drugs

DOI

ISSN

0012-6667

Publication Date

1981

Volume

22 Suppl 1

Start / End Page

60 / 64

Location

New Zealand

Related Subject Headings

  • Rabbits
  • Pharmacology & Pharmacy
  • Moxalactam
  • Meningitis, Haemophilus
  • Kinetics
  • Cephamycins
  • Cephalosporins
  • Cefotaxime
  • Cefoperazone
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Durack, D. T., & Perfect, J. R. (1981). Potential value of cefoperazone in bacterial meningitis: experimental studies. Drugs, 22 Suppl 1, 60–64. https://doi.org/10.2165/00003495-198100221-00013
Durack, D. T., and J. R. Perfect. “Potential value of cefoperazone in bacterial meningitis: experimental studies.Drugs 22 Suppl 1 (1981): 60–64. https://doi.org/10.2165/00003495-198100221-00013.
Durack DT, Perfect JR. Potential value of cefoperazone in bacterial meningitis: experimental studies. Drugs. 1981;22 Suppl 1:60–4.
Durack, D. T., and J. R. Perfect. “Potential value of cefoperazone in bacterial meningitis: experimental studies.Drugs, vol. 22 Suppl 1, 1981, pp. 60–64. Pubmed, doi:10.2165/00003495-198100221-00013.
Durack DT, Perfect JR. Potential value of cefoperazone in bacterial meningitis: experimental studies. Drugs. 1981;22 Suppl 1:60–64.
Journal cover image

Published In

Drugs

DOI

ISSN

0012-6667

Publication Date

1981

Volume

22 Suppl 1

Start / End Page

60 / 64

Location

New Zealand

Related Subject Headings

  • Rabbits
  • Pharmacology & Pharmacy
  • Moxalactam
  • Meningitis, Haemophilus
  • Kinetics
  • Cephamycins
  • Cephalosporins
  • Cefotaxime
  • Cefoperazone
  • Animals