Unusual DNA sequences associated with the ends of yeast chromosomes.

Published

Journal Article

The genome of the yeast Saccharomyces cerevisiae, like those of other eukaryotes, contains multiple sequences that hybridize with a poly(GT) probe. We have shown previously that some of the sequences that hybridize with the poly(GT) probe are located near the tips of the yeast chromosomes. We report here that many of the remaining poly(GT)-hybridizing sequences are associated with a family of putative replication origins localized near the chromosome ends. These sequences have the general form poly(C1-3A), similar to sequences reported to occur at the tips of chromosomes in the accompanying paper. In addition to poly(C1-3A) tracts, yeast cells contain tracts of alternating C and A bases, similar to those seen in mammalian genomes. These results are used as the basis for a new model of telomere replication.

Full Text

Duke Authors

Cited Authors

  • Walmsley, RW; Chan, CS; Tye, BK; Petes, TD

Published Date

  • July 1984

Published In

Volume / Issue

  • 310 / 5973

Start / End Page

  • 157 - 160

PubMed ID

  • 6377091

Pubmed Central ID

  • 6377091

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/310157a0

Language

  • eng