Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes.

Journal Article

Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions were derived for the fixation probability, mean time to fixation or loss, and mean conditional fixation time for a variant repeat with an arbitrary initial frequency. It was shown that a small conversional advantage or disadvantage for the variant repeat (higher or lower probability of producing two variant genes by conversion than two wild-type genes) can have a dramatic effect on the probability of fixation. The results imply that intrachromosomal gene conversion can act sufficiently rapidly to be an important mechanism for maintaining sequence homogeneity among repeated genes.

Full Text

Duke Authors

Cited Authors

  • Nagylaki, T; Petes, TD

Published Date

  • February 1982

Published In

Volume / Issue

  • 100 / 2

Start / End Page

  • 315 - 337

PubMed ID

  • 7106560

International Standard Serial Number (ISSN)

  • 0016-6731

Language

  • eng

Conference Location

  • United States