Transposed LEU2 gene of Saccharomyces cerevisiae is regulated normally.

Journal Article

The repression of beta-isopropylmalate dehydrogenase, the LEU2 gene product, by leucine and leucine plus threonine was unaffected by the transposition of LEU2 from its original locus on chromosome III to a new locus within the ribosomal deoxyribonucleic acid gene cluster on chromosome XII. Since the expression of the LEU2 gene is probably controlled at a pretranslational level, we conclude that the recombinant plasmid used for transformation carries regulatory information in addition to LEU2 structural information.

Full Text

Duke Authors

Cited Authors

  • Kohlhaw, GB; Hsu, YP; Lemmon, RD; Petes, TD

Published Date

  • November 1, 1980

Published In

Volume / Issue

  • 144 / 2

Start / End Page

  • 852 - 855

PubMed ID

  • 7000755

International Standard Serial Number (ISSN)

  • 0021-9193

Language

  • eng

Conference Location

  • United States