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Near-infrared spectroscopy for monitoring muscle oxygenation.

Publication ,  Journal Article
Boushel, R; Piantadosi, CA
Published in: Acta Physiol Scand
April 2000

Near-infrared spectroscopy (NIRS) is a non-invasive method for monitoring oxygen availability and utilization by the tissues. In intact skeletal muscle, NIRS allows semi-quantitative measurements of haemoglobin plus myoglobin oxygenation (tissue O2 stores) and the haemoglobin volume. Specialized algorithms allow assessment of the oxidation-reduction (redox) state of the copper moiety (CuA) of mitochondrial cytochrome c oxidase and, with the use of specific tracers, accurate assessment of regional blood flow. NIRS has demonstrated utility for monitoring changes in muscle oxygenation and blood flow during submaximal and maximal exercise and under pathophysiological conditions including cardiovascular disease and sepsis. During work, the extent to which skeletal muscles deoxygenate varies according to the type of muscle, type of exercise and blood flow response. In some instances, a strong concordance is demonstrated between the fall in O2 stores with incremental work and a decrease in CuA oxidation state. Under some pathological conditions, however, the changes in O2 stores and redox state may diverge substantially.

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Published In

Acta Physiol Scand

DOI

ISSN

0001-6772

Publication Date

April 2000

Volume

168

Issue

4

Start / End Page

615 / 622

Location

England

Related Subject Headings

  • Spectroscopy, Near-Infrared
  • Regional Blood Flow
  • Physiology
  • Oxygen Consumption
  • Oximetry
  • Muscle, Skeletal
  • Humans
  • Animals
  • 3208 Medical physiology
  • 1116 Medical Physiology
 

Citation

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Boushel, R., & Piantadosi, C. A. (2000). Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand, 168(4), 615–622. https://doi.org/10.1046/j.1365-201x.2000.00713.x
Boushel, R., and C. A. Piantadosi. “Near-infrared spectroscopy for monitoring muscle oxygenation.Acta Physiol Scand 168, no. 4 (April 2000): 615–22. https://doi.org/10.1046/j.1365-201x.2000.00713.x.
Boushel R, Piantadosi CA. Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand. 2000 Apr;168(4):615–22.
Boushel, R., and C. A. Piantadosi. “Near-infrared spectroscopy for monitoring muscle oxygenation.Acta Physiol Scand, vol. 168, no. 4, Apr. 2000, pp. 615–22. Pubmed, doi:10.1046/j.1365-201x.2000.00713.x.
Boushel R, Piantadosi CA. Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand. 2000 Apr;168(4):615–622.

Published In

Acta Physiol Scand

DOI

ISSN

0001-6772

Publication Date

April 2000

Volume

168

Issue

4

Start / End Page

615 / 622

Location

England

Related Subject Headings

  • Spectroscopy, Near-Infrared
  • Regional Blood Flow
  • Physiology
  • Oxygen Consumption
  • Oximetry
  • Muscle, Skeletal
  • Humans
  • Animals
  • 3208 Medical physiology
  • 1116 Medical Physiology