Near-infrared spectroscopy. Clinical applications.

Journal Article (Journal Article;Review)

NIRS is an attractive monitoring technology because it is a noninvasive, real-time, repeatable method that allows for regional assessment of the adequacy of tissue oxygenation. It is able to evaluate the oxygenation state of hemoglobin in tissue and redox state of cyt a1,a3, which reflects the overall activity of oxidative metabolism in the cells. The primary technical limitation of current technology is the inability to measure accurately the optical pathlength online, limiting the ability to quantify precisely concentrations of oxygen-dependent chromophores. Even with this limitation, NIRS can provide unique and valuable in vivo metabolic information without invasive intervention.

Full Text

Duke Authors

Cited Authors

  • Simonson, SG; Piantadosi, CA

Published Date

  • October 1996

Published In

Volume / Issue

  • 12 / 4

Start / End Page

  • 1019 - 1029

PubMed ID

  • 8902382

International Standard Serial Number (ISSN)

  • 0749-0704

Digital Object Identifier (DOI)

  • 10.1016/s0749-0704(05)70290-6


  • eng

Conference Location

  • United States