Oxidative metabolism in sepsis and sepsis syndrome.

Published

Journal Article (Review)

The high mortality associated with sepsis syndrome and multiple organ dysfunction syndrome has persisted despite extraordinary research efforts in the laboratory and the intensive care unit. These syndromes produce systemic tissue damage that is likely to result from widespread inflammation and subsequent endothelial injury. This article reviews the oxidative metabolic effects and responses to sepsis syndrome at several levels: the oxygen transport system, the cell, and the mitochondrion. Specifically, aerobic metabolism of carbon substrates and oxygen is altered in sepsis. As a result of systemic inflammation and nonmetabolic oxygen use, oxidative stress may occur both outside and inside the cell. The consequences of these oxidative processes during sepsis may be ongoing cell damage mediated by reactive oxygen and nitrogen oxide species that culminates in multisystem organ failure.

Full Text

Duke Authors

Cited Authors

  • Taylor, DE; Piantadosi, CA

Published Date

  • September 1995

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 122 - 135

PubMed ID

  • 7496449

Pubmed Central ID

  • 7496449

Electronic International Standard Serial Number (EISSN)

  • 1557-8615

International Standard Serial Number (ISSN)

  • 0883-9441

Digital Object Identifier (DOI)

  • 10.1016/0883-9441(95)90003-9

Language

  • eng