Isolation of mycobacteria in patients with pulmonary alveolar proteinosis.

Journal Article (Journal Article)

Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by accumulation of proteinaceous material in the alveoli of affected individuals. Pulmonary infections appear to develop with increased frequency in these patients. The increased rate of infection has been attributed to immunologic aberrations, such as impaired alveolar macrophage function, particularly when uncommon pathogens are involved. Among those pathogens, Nocardia asteroides and Mycobacterium tuberculosis have appeared most often in case reports in the literature. Mycobacterium avium-intracellulare (MAI) has rarely been isolated in these patients. We report an unusually high incidence of MAI isolation from lavage fluid in 8 of 19 consecutive patients who underwent therapeutic lung lavage for relief of symptomatic PAP, and summarize the available literature on isolation of potential respiratory pathogens in PAP.

Full Text

Duke Authors

Cited Authors

  • Witty, LA; Tapson, VF; Piantadosi, CA

Published Date

  • March 1994

Published In

Volume / Issue

  • 73 / 2

Start / End Page

  • 103 - 109

PubMed ID

  • 8152364

International Standard Serial Number (ISSN)

  • 0025-7974

Digital Object Identifier (DOI)

  • 10.1097/00005792-199403000-00003


  • eng

Conference Location

  • United States