Behavior of the copper band of cytochrome c oxidase in rat brain during FC-43-for-blood substitution.
Journal Article (Journal Article)
FC-43-for-blood substitution experiments were conducted in anesthetized rats to evaluate NIR spectroscopic responses by living brain to exchange transfusion at very low hematocrits. The NIR responses to the exchange process also assess the ability of multiwavelength algorithms to measure independent changes in the relative amounts of Hb, tHbO2 and oxidized cytochrome a,a3 in the tissue. These data indicate that FC-43 circulation at high FIO2 (1.00) delivers sufficient O2 to the rat brain to maintain the oxidation state of the mitochondrial oxidase near pre-exchange values. The results also confirm the ability of four wavelength algorithms to distinguish changes in the oxidized copper band of cytochrome a,a3 from changes in absorption by Hb and HbO2.
Full Text
Duke Authors
Cited Authors
- Piantadosi, CA
Published Date
- 1989
Published In
Volume / Issue
- 248 /
Start / End Page
- 81 - 90
PubMed ID
- 2551144
Pubmed Central ID
- 2551144
International Standard Serial Number (ISSN)
- 0065-2598
Digital Object Identifier (DOI)
- 10.1007/978-1-4684-5643-1_11
Language
- eng
Conference Location
- United States