Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids.

Journal Article (Journal Article)

Approximately 5-10% of ascitic fluids from 411 NZB myeloma tumors were found to possess either antinuclear (ANA) or Coombs antibodies. Some fluids showed anti-SM specificity, which is thought to be unique to systemic lupus erythematosus (SLE). In addition, the ascitic fluids were found to contain large amounts of DNA and Sm autoantigens. Further passage of ANA-positive myelomas indicated that the autoantibodies were not products of the myeloma cells themselves. The sporadic appearance of unsuspected autoantibodies in ascitic fluids may cause confusion when working with myeloma or with hybridoma reagents. Furthermore, the development of SLE-specific anti-Sm antibodies in this context suggests parallels between myeloma development and autoimmunity.

Full Text

Duke Authors

Cited Authors

  • Eisenberg, RA; Pisetsky, D; Cohen, PL

Published Date

  • June 1, 1985

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 337 - 345

PubMed ID

  • 3872756

International Standard Serial Number (ISSN)

  • 0090-1229

Digital Object Identifier (DOI)

  • 10.1016/0090-1229(85)90094-7


  • eng

Conference Location

  • United States